CA19127 - Cognitive decline in Nephro-Neurology: European Cooperative Target (CONNECT)

Fragmentation between neurological and nephrological expertise has frustrated research into the mechanism of cognitive decline secondary to kidney disease. By for the first time bringing these fields together in CONNECT we establish a novel multidisciplinary field to improve patient diagnosis and care.

The developed world is experiencing a growing number of patients with chronic kidney disease (CKD), a complex systemic and potentially fatal disease. With improved long-term life expectancy as the result of kidney replacement therapies, more attention has been given to comorbidities, including cognitive impairment. In CKD patients, both the central and peripheral nervous system are frequently affected. Eventually, this decreases quality of life and eventually dementia with loss of independence in everyday activities.

CONNECT aims to coordinate research on cognitive impairment in CKD. This requires exchanging clinical information between nephrologists and neurologists, and between neuroscientists and kidney physiologists, guided by big data analysts. This collaborative network will define new experimental paradigms, their translational value and, in turn, focus on new interventions in the field of cognitive impairment.

At the core of this COST Action lie activities that bridge the gaps between these fields and prepare early-stage researchers and clinicians to start new research lines. The interdisciplinary consortium from 22 countries will focus on 1) Pre-clinical research, 2) Clinical trials, 3) clinical practice, 4) Data management and analytics, and 5) Inclusiveness and dissemination of the Action. This COST Action will alleviate disparities in CKD patient care and enable breakthrough research enabling patient diagnosis and early treatments.