Dr Jacques Neefjes
Head of Department of Cell and Chemical Biology, LUMC, Leiden
He is chairman of the scientific council of the Dutch Children Oncology Fund KiKa and has been chairman of the scientific council of the Dutch Cancer Society KWF.
Dr Jacques Neefjes has made many seminal contributions to the fields of immunology, infection diseases, cell biology and chemical biology. His research has centered around the cell biology of MHC class I and MHC class II associated antigen presentation. These pathways is critical in tumorimmunotherapy. Neefjes has unraveled many steps in these pathways including the definition of DRiPs, the definition of the MIIC, the molecular control of vesicle transport by motor proteins, the control of lysosomal transport by the ER and cholesterol and many other issues central in cell biology. Collectively, his work has uncovered many steps in the cell biology of antigen presentation by MHC class I and MHC class II molecules. His activities in the area of chemical immunology has yielded new antibiotic targets and lead structures that support the host in bacterial clearance. This novel concept was the basis of his latest findings showing how bacterial infections cause cancer which will have broad implication in understanding as well as preventing cancer.
Neefjes has published over 230 papers in peer reviewed journals with an H index of over 80. He is a member of the Dutch Royal Society of Sciences and a member of the Norske Videnskaps Akademi.
Honours and Awards
1990 Antoni van Leeuwenhoek award
1992 EMBO long term fellowship
1996 Golden Medal of the Royal Dutch Chemical Society (KNCV)
1996 Pioneer Grant
2007 Elected member EMBO
2009 ERC Advanced Grant
2010 Elected member European Academy of Cancer Sciences
2013 Elected member Academia Europaea
2013 Recipient and main applicant Gravity Program Institute for Chemical Immunology
2014 Elected member of the Norwegian Academy of Science and Letters
2015 Elected member and Dutch representative in the EU COST Scientific Committee
2015 Elected member of the Dutch Royal Society of Sciences and Arts (KNAW)
2015 van Loghem Lecture, the Dutch award for research in Immunology
2016 ERC Advanced Grant
2012 Ruysch lecture AMC, Amsterdam
2012 Beatty Lecture, McGill University, Montreal, Canada