Description
Pancreatic cancer (PC) has a high mortality rate and is projected to become a massive public health problem in Europe. This Action will boost research on prevention of PC, particularly in the discovery of genetic risk factors, risk stratification, identification of biomarkers for early detection and patient monitoring, elucidation of biological mechanisms and functional pharmacogenomics for personalized medicine. These aims will be attained by expanding an existing interdisciplinary network.
The Action will be organized in the following working groups:
- Disease risk profiling. This WG will use germline genetic variants, epigenetics, transcriptomics and environmental factors to model disease risk and apply risk stratification scores to better select individuals eligible to be screened for PC or its precursors.
- Non-invasive biomarkers. This WG will apply state-of-the-art liquid biopsies for the detection and characterization of circulating tumor cells and DNA, tumor-derived exosomes, tumor-educated platelets, epigenetic markers, and will test their diagnostic value for PC precursors and early-stage PC.
- Tumor profiling. Genomic, epigenomic and transcriptional profiling of PC and its precursors in a multiregional analysis fashion will be used to identify novel biomarkers with prognosis and predictive value for PC patient stratification.
- Functional genomics and therapy. This WG will functionally validate candidate genetic variants from germline or tumor studies by using cutting-edge approaches such as CRISPR-Cas9 gene editing. It will also generate novel approaches such as organoids / zebrafish avatars to implement (chemo)therapeutic strategies based on the patient in an effort to implement personalized medicine for PC.
Action keywords
Pancreatic cancer - Biomarkers - Genetic susceptibility - Prevention - Early detection
Management Committee
Country | MC Member |
---|---|
Albania | |
Belgium | |
Belgium | |
Bosnia and Herzegovina | |
Bosnia and Herzegovina | |
Croatia | |
Croatia | |
Czech Republic | |
Czech Republic | |
Denmark | |
Denmark | |
Estonia | |
France | |
France | |
Germany | |
Germany | |
Greece | |
Greece | |
Hungary | |
Hungary | |
Iceland | |
Ireland | |
Ireland | |
Israel | |
Israel | |
Italy | |
Italy | |
Latvia | |
Latvia | |
Lithuania | |
Malta | |
Netherlands | |
Netherlands | |
North Macedonia | |
North Macedonia | |
Norway | |
Norway | |
Poland | |
Poland | |
Portugal | |
Portugal | |
Romania | |
Romania | |
Serbia | |
Serbia | |
Slovakia | |
Slovakia | |
Slovenia | |
Spain | |
Spain | |
Türkiye | |
Türkiye | |
United Kingdom | |
United Kingdom |
Main Contacts
Action Contacts
COST Staff
Leadership
Role | Leader |
---|---|
Action Chair | |
Action Vice-Chair | |
Grant Holder Scientific Representative | |
Science Communication Coordinator | |
Grant Awarding Coordinator | |
WG1 Leader | |
WG2 Leader | |
WG3 Leader | |
WG4 Leader |
Additional roles
Role | Leader |
---|---|
Training School Coordinator | |
Intellectual property/tech transfer coordinator | |
Website and seminar coordinator |
Working Groups
Number | Title | Leader |
---|---|---|
1 | Disease risk profiling | |
2 | Non-invasive biomarkers | |
3 | Tumor profiling | |
4 | Functional genomics and therapy |
Express your interest to join any of the working groups by applying below.
It is required to have an e-COST profile to submit your application. If needed, create it first and then click 'Apply'.
ApplyMembership
Name | Working Group | Country |
---|---|---|
WG 1, WG 2, WG 3, WG 4 | Germany | |
WG 1, WG 2, WG 3 | Latvia | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 4 | United States | |
WG 1 | Italy | |
WG 1 | Poland | |
WG 1 | Poland | |
WG 1, WG 3 | France | |
WG 1, WG 2, WG 3, WG 4 | Italy | |
WG 1, WG 2, WG 3, WG 4 | Italy | |
WG 1, WG 2, WG 3, WG 4 | Italy | |
WG 1, WG 2, WG 3 | Ireland | |
WG 1, WG 2, WG 3 | Lithuania | |
WG 1, WG 2 | United Kingdom | |
WG 1, WG 2, WG 3, WG 4 | Germany | |
WG 1, WG 2, WG 3 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Italy | |
WG 1, WG 2, WG 3 | Italy | |
WG 1, WG 2, WG 3, WG 4 | Italy | |
WG 1, WG 2, WG 3 | North Macedonia | |
WG 1 | Italy | |
WG 1, WG 2 | Germany | |
WG 1, WG 2, WG 3, WG 4 | Germany | |
WG 1, WG 2 | Spain | |
WG 1, WG 2, WG 3 | Netherlands | |
WG 1, WG 2, WG 3 | Lithuania | |
WG 1, WG 2 | ||
WG 1, WG 2, WG 3 | Italy | |
WG 1 | ||
WG 1, WG 2, WG 3, WG 4 | Netherlands | |
WG 1, WG 2 | Croatia | |
WG 1, WG 2, WG 3, WG 4 | Italy | |
WG 1, WG 2, WG 3, WG 4 | Brazil | |
WG 1, WG 2, WG 4 | Greece | |
WG 1, WG 2 | ||
WG 1, WG 2, WG 3 | Türkiye | |
WG 1, WG 2, WG 3 | Serbia | |
WG 1, WG 2 | Ireland | |
WG 1, WG 2 | Serbia | |
WG 1, WG 2, WG 4 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | ||
WG 1, WG 2 | Czechia | |
WG 1 | Germany | |
WG 1, WG 2 | Slovakia | |
WG 1, WG 2, WG 3 | United Kingdom | |
WG 1, WG 2, WG 3, WG 4 | Italy | |
WG 1 | Italy | |
WG 1 | Portugal | |
WG 1, WG 2, WG 3, WG 4 | Italy | |
WG 1, WG 3 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Serbia | |
WG 1, WG 2, WG 3, WG 4 | Brazil | |
WG 1, WG 2, WG 3, WG 4 | Italy | |
WG 1, WG 2, WG 3, WG 4 | China | |
WG 1 | Belgium | |
WG 1, WG 2 | Spain | |
WG 1, WG 2, WG 3 | Latvia | |
WG 1 | Estonia | |
WG 1, WG 4 | United Kingdom | |
WG 1, WG 2, WG 3 | Poland | |
WG 1, WG 2, WG 3, WG 4 | Denmark | |
WG 1, WG 2, WG 3 | Türkiye | |
WG 1, WG 4 | Bosnia & Herzegovina | |
WG 1, WG 2, WG 3, WG 4 | France | |
WG 1, WG 4 | Bosnia & Herzegovina | |
WG 1, WG 2 | Spain | |
WG 1 | Belgium | |
WG 1, WG 2, WG 3 | ||
WG 1, WG 2 | Portugal | |
WG 1, WG 2, WG 3, WG 4 | Germany | |
WG 1, WG 2, WG 4 | Moldova | |
WG 1, WG 2, WG 3 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Romania | |
WG 1, WG 2, WG 3, WG 4 | Romania | |
WG 1, WG 2, WG 3 | Romania | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Romania | |
WG 1, WG 3 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Spain | |
WG 1, WG 2, WG 3, WG 4 | Italy | |
WG 1, WG 2, WG 3 | Spain | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 2, WG 4 | Norway | |
WG 1, WG 2, WG 3 | Romania | |
WG 1, WG 2, WG 3, WG 4 | Italy | |
WG 1, WG 2, WG 3, WG 4 | Germany | |
WG 1 | Romania | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1 | Germany | |
WG 1, WG 2 | Albania | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 2, WG 3 | Romania | |
WG 1 | Bosnia & Herzegovina | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Austria | |
WG 1, WG 2, WG 3, WG 4 | Lithuania | |
WG 1 | Hungary | |
WG 1 | Germany | |
WG 1, WG 3, WG 4 | Spain | |
WG 1, WG 3, WG 4 | Spain | |
WG 1, WG 2 | Spain | |
WG 1 | Türkiye | |
WG 1, WG 3, WG 4 | Türkiye | |
WG 1, WG 2 | Slovakia | |
WG 1, WG 2 | Slovakia | |
WG 1, WG 2, WG 3 | Albania | |
WG 1, WG 2 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 2, WG 3 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Greece | |
WG 1, WG 2, WG 3, WG 4 | Greece | |
WG 1, WG 2, WG 3 | Greece | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1 | Türkiye | |
WG 1, WG 3 | Türkiye | |
WG 1, WG 2, WG 4 | Poland | |
WG 1 | Italy | |
WG 1, WG 2, WG 3, WG 4 | United Kingdom | |
WG 1, WG 2, WG 4 | Greece | |
WG 1, WG 2, WG 4 | Greece | |
WG 1, WG 2, WG 3, WG 4 | United Kingdom | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 3, WG 4 | Albania | |
WG 1, WG 2 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 3 | Türkiye | |
WG 1, WG 2 | United Kingdom | |
WG 1, WG 2 | United Kingdom | |
WG 1, WG 3, WG 4 | Poland | |
WG 1, WG 2 | Bosnia & Herzegovina | |
WG 1, WG 2, WG 3, WG 4 | Albania | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 3 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |