Primary constitutional MLH1 epimutations: a focal epigenetic event
- Author(s): Estela Dámaso, Adela Castillejo et al.
- Publisher(s): www.nature.com/bjc
- Published online 04 October 2018
Colorectal cancer (CRC) is one of the most frequent neoplasms worldwide and an important cause of morbidity in the developed world. It is necessary to identify individuals with a medium-high CRC risk in order to develop adequate preventive measures. The identification of inherited genetic factors involved in CRC susceptibility can help to profile individual disease risk and may enable early screening and treatment monitoring.
Cooperation Studies on Inherited Susceptibility to Colorectal Cancer, COST Action BM1206 (2013-2017) was chaired by Dr Sergei Castellvi-Bel.