Electroporation is a platform technology for drug and gene delivery. When applied to cell in vitro or tissues in vivo, it leads to an increase in membrane permeability for molecules which otherwise cannot enter the cell. The therapeutic effectiveness of delivered chemotherapeutics or nucleic acids depends greatly on their successful and efficient delivery to the target tissue. Therefore, the understanding of different principles of drug and gene delivery is necessary and needs to be taken into account according to the specificity of their delivery to tumors and/or normal tissues.
Publication date:
2015
Action:
TD1104
- Author(s): Sersa G., Teissie J., Cemazar M., Signori E., Kamensek, U., Marshall G., Miklavcic D
- Publisher(s): Springer
- http://link.springer.com/article/10.1007%2Fs00262-015-1724-2