Protein profiling probes, designed and prepared by synthetic chemists, have high potential as tools to study proteomes. We aim to bring together a group of chemical biologists that share common interests in their attempts to design and synthesize probes for chemical proteomics and for unraveling important biosynthetic pathways. Examples of such probes are those with which specific proteins or protein families can be targeted within a proteome for enrichment and subsequent identification and analysis. Synthetic probes directed at enzymes (also referred to as activity-based probes) report on the presence of active enzymes, and not on mere polypeptide expression levels. Alternatively, synthetic probes can be used to identify unknown receptors as well as post-translational modification events. New probes and innovative methods of analysis are urgently needed, and with this Action we will provide a common platform to develop and share these important tools for fundamental and applied biological and biomedical research.
Chemical proteomics - Chemical biology - Protein profiling - Activity-based probes - Proteasome - Post-translational modification
