Description
All cells face the vital challenge of sensing their environments and responding in appropriate ways. This
process is accomplished by transmembrane signal transduction, which is present in every species and
governs every aspect of how an organism functions. In regard to human health, there is a huge drive to
understand how transmembrane signal transduction networks function on the molecular, cellular and
physiological level so that drugs can be designed to modulate different aspects of the signal transduction
cascade in highly specific ways. Despite significant progress in understanding the individual components,
signal transduction as a whole is not fully understood. Fundamental questions remain regarding how
different signalling pathways are activated and modulated in precise and reproducible ways. Filling this gap
in knowledge is absolutely necessary to advance the next generation of drugs that will achieve therapeutic
efficacy while minimizing side effects. A prime example of this research challenge is the large family of G
protein-coupled receptors (GPCRs), which are the target of more than a third of all marketed drugs. The
COST Action ERNEST (European Research Network on Signal Transduction) will tackle this challenge by
uniting scientists from different disciplines spanning the molecular, cellular, physiological, and clinical
perspectives. This network of diverse investigators will be uniquely able to synergistically develop an
unprecedented comprehensive understanding of signal transduction that will advance drug design efforts in
Europe, for the benefit of societies and human health worldwide.
Action keywords
Signal transduction - GPCR - molecular mechanisms - drug design - database resources
Management Committee
Country | MC Member |
---|---|
Albania | |
Austria | |
Austria | |
Belgium | |
Belgium | |
Bosnia and Herzegovina | |
Bosnia and Herzegovina | |
Bulgaria | |
Bulgaria | |
Croatia | |
Czech Republic | |
Czech Republic | |
Denmark | |
Denmark | |
Estonia | |
Finland | |
Finland | |
France | |
France | |
Germany | |
Germany | |
Greece | |
Greece | |
Hungary | |
Hungary | |
Ireland | |
Ireland | |
Israel | |
Israel | |
Italy | |
Italy | |
Latvia | |
Latvia | |
Lithuania | |
Luxembourg | |
Luxembourg | |
Malta | |
Malta | |
Moldova | |
Moldova | |
Netherlands | |
Netherlands | |
North Macedonia | |
Norway | |
Norway | |
Poland | |
Poland | |
Portugal | |
Portugal | |
Romania | |
Romania | |
Serbia | |
Serbia | |
Slovenia | |
Slovenia | |
Spain | |
Sweden | |
Sweden | |
Switzerland | |
Switzerland | |
Türkiye | |
Türkiye | |
United Kingdom | |
United Kingdom |
Main Contacts
Action Contacts
COST Staff
Leadership
Role | Leader |
---|---|
Action Chair | |
Action Vice-Chair | |
Grant Holder Scientific Representative | |
Science Communication Coordinator | |
Grant Awarding Coordinator | |
WG1 Leader | |
WG2 Leader | |
WG3 Leader | |
WG4 Leader | |
WG5 Leader |
Additional roles
Role | Leader |
---|---|
Grant Awarding Committee | |
Grant Awarding Committee | |
Grant Awarding Committee | |
Mapping Group Co-leader | |
Mapping Group Co-leader | |
Mapping Group Co-leader | |
Mapping Group Co-leader | |
WG1 Co-leader | |
WG2 Co-leader | |
WG3 Co-leader | |
WG4 Co-leader | |
WG5 Co-leader | |
Equality & Inclusiveness Officer | |
Early Career Committee | |
Early Career Committee | |
Early Career Committee | |
Science Communication Co-Coordinator | |
Science Communication Co-Coordinator |
Working Groups
Number | Title | Leader |
---|---|---|
1 | Macromolecular interactions in signalling pathways | |
2 | Biological roles of signal transduction | |
3 | Molecular modulators of signal transduction | |
4 | Advanced methodologies and technologies | |
5 | Public web resources |
Membership
Name | Working Group | Country |
---|---|---|
WG 1, WG 2, WG 4 | Germany | |
WG 1, WG 3, WG 5 | ||
WG 1, WG 2, WG 3, WG 4 | Czechia | |
WG 1, WG 3, WG 5 | Germany | |
WG 1, WG 3, WG 4 | Spain | |
WG 1, WG 3, WG 4 | Estonia | |
WG 1, WG 2, WG 3, WG 4 | United States | |
WG 1, WG 3, WG 5 | Germany | |
WG 1, WG 4 | Slovenia | |
WG 1, WG 3, WG 4 | Germany | |
WG 1 | Albania | |
WG 1, WG 2, WG 3 | Greece | |
WG 1, WG 2, WG 3 | Greece | |
WG 1, WG 3, WG 4, WG 5 | Sweden | |
WG 1, WG 2, WG 3, WG 4 | Belgium | |
WG 1, WG 2, WG 3, WG 4 | Germany | |
WG 1, WG 2, WG 3, WG 4 | United Kingdom | |
WG 1, WG 3 | United Kingdom | |
WG 1, WG 2, WG 3, WG 4 | Netherlands | |
WG 1, WG 2, WG 3 | ||
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 3 | Greece | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | Spain | |
WG 1, WG 2, WG 3 | ||
WG 1, WG 3, WG 5 | Türkiye | |
WG 1, WG 2, WG 3, WG 4 | ||
WG 1, WG 2, WG 4, WG 5 | ||
WG 1, WG 2 | Türkiye | |
WG 1, WG 3 | Switzerland | |
WG 1, WG 2, WG 3 | Belgium | |
WG 1, WG 3, WG 5 | Italy | |
WG 1, WG 2, WG 3 | Czechia | |
WG 1, WG 2, WG 4 | Germany | |
WG 1, WG 3 | Austria | |
WG 1, WG 2, WG 4 | Czechia | |
WG 1 | Germany | |
WG 1, WG 5 | Denmark | |
WG 1, WG 2, WG 3, WG 4, WG 5 | Spain | |
WG 1, WG 2, WG 3 | France | |
WG 1, WG 3, WG 5 | United Kingdom | |
WG 1, WG 2 | Croatia | |
WG 1, WG 2, WG 3, WG 4 | Israel | |
WG 1, WG 4 | Ireland | |
WG 1, WG 2, WG 3, WG 4 | Luxembourg | |
WG 1, WG 2, WG 3, WG 4 | Luxembourg | |
WG 1, WG 3 | Norway | |
WG 1, WG 2, WG 3, WG 4 | Norway | |
WG 1, WG 2, WG 3 | Netherlands | |
WG 1, WG 2, WG 4 | Portugal | |
WG 1, WG 3, WG 4 | Poland | |
WG 1, WG 2, WG 3 | Bosnia & Herzegovina | |
WG 1, WG 2 | Bulgaria | |
WG 1, WG 2 | Bulgaria | |
WG 1, WG 4 | Switzerland | |
WG 1, WG 3, WG 4 | Germany | |
WG 1, WG 4 | Ireland | |
WG 1, WG 2, WG 3 | France | |
WG 1, WG 3, WG 4 | Italy | |
WG 1, WG 3, WG 4, WG 5 | Spain | |
WG 1 | Spain | |
WG 1, WG 2, WG 3, WG 4 | ||
WG 1, WG 2, WG 3, WG 5 | United Kingdom | |
WG 1, WG 2, WG 3 | Germany | |
WG 1, WG 3, WG 4, WG 5 | Germany | |
WG 1, WG 3 | Sweden | |
WG 1, WG 4 | China | |
WG 1, WG 2, WG 3, WG 4 | Sweden | |
WG 1, WG 2, WG 3, WG 4, WG 5 | ||
WG 1, WG 3 | Austria | |
WG 1, WG 3, WG 4, WG 5 | United States | |
WG 1, WG 3, WG 5 | Spain | |
WG 1, WG 2, WG 3, WG 4 | Italy | |
WG 1, WG 2, WG 3, WG 4 | Türkiye | |
WG 1, WG 4 | Türkiye | |
WG 1 | Denmark | |
WG 1, WG 2, WG 3 | Spain | |
WG 2 | Denmark | |
WG 2 | Poland | |
WG 2, WG 5 | Serbia | |
WG 2, WG 3 | Hungary | |
WG 2, WG 3 | Italy | |
WG 2, WG 3, WG 4 | ||
WG 2, WG 3, WG 4 | Italy | |
WG 2 | Spain | |
WG 2, WG 3 | United States | |
WG 2, WG 4 | ||
WG 2, WG 3 | Spain | |
WG 2, WG 3, WG 4 | Belgium | |
WG 2, WG 3, WG 4, WG 5 | Austria | |
WG 2 | Moldova | |
WG 2 | Moldova | |
WG 2, WG 3, WG 4 | Finland | |
WG 2 | ||
WG 2 | North Macedonia | |
WG 2 | ||
WG 2 | ||
WG 2 | Portugal | |
WG 2 | ||
WG 2, WG 3 | ||
WG 2 | Slovenia | |
WG 2 | Türkiye | |
WG 2 | Türkiye | |
WG 2 | Belgium | |
WG 2 | Bosnia & Herzegovina | |
WG 2 | Slovenia | |
WG 2 | Spain | |
WG 2, WG 3 | Spain | |
WG 2, WG 3, WG 4 | ||
WG 2 | Spain | |
WG 2, WG 3 | Spain | |
WG 2, WG 3, WG 4 | Bosnia & Herzegovina | |