The importance of iron-sulfur (Fe/S) proteins for human life and the comprehension, at molecular and cellular level, of their biogenesis is documented by an increasing number of diseases linked to functional impairment of these proteins and of their maturation processes. Fe/S protein biogenesis needs to guarantee that the right metal reaches the right binding site in any subcellular compartments, through specific cellular pathways, which control the steps of Fe/S cluster assembly and transfer. This Action is an intersectoral, pan-European network to: address Fe/S protein biogenesis in living systems; investigate pathophysiological mechanisms underlying human diseases related to Fe/S protein biogenesis dysfunctions; provide a molecular view of Fe/S protein assembly processes and trafficking pathways in the context of the cellular metallomes. The Action will build a joined research agenda and a network with different expertise and infrastructures, henceforth it will be able to i) support Early Career Investigators and research groups from Inclusiveness Target Countries; ii) frame the research of individual groups within wider scenarios; iii) achieve scientific deliverables that could not be reached without knowledge and infrastructure sharing based approaches. The understanding of molecular mechanisms at the basis of Fe/S protein biogenesis needs to be addressed by a team of chemists, biologists and geneticists in order to provide a full picture of the possible and feasible cures to these genetic diseases. The Action will foster knowledge exchange among different areas, explore the intersection of fundamental science with applications, act as incubator for translational studies, diffuse good practice of gathering different expertise.
Iron-sulfur protein biogenesis - cellular biology - spectroscopy - Iron trafficking and homeostasis - structural biology
