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CMST COST Action CM0703
Systems Chemistry

The main objective of the Action is to investigate autocatalytic reaction sytems within supramolecular, prebiotic, and other fields of chemistry and to develop methods for their integration into dynamic supersystems.

Systems chemistry is the joint effort of prebiotic and supramolecular chemistry assisted by computer science from theoretical chemistry, biology, and complex systems research to tackle dynamic supersystem integration including at least one autocatalytic subsystem. It is the bottom-up pendant of systems biology towards synthetic biology. The origin of life is seen as a major stimulus to organize research but the field is open for chemistries of limited prebiotic plausibility. Subsystems may be classified as genetic, metabolic, or compartiment-building. Pairwise integration into higher organized supersystems is expected to yield the knowledge enabling later the triple integration into minimal chemical cells. The integration approach will necessarily link to the question of asymmetric autocatalysis and chiral symmetry breaking, while the key challenge is to find the roots of Darwinian evolvability in chemical systems. 5 workgroups will define a trigonal bipyramid, where the axis  theory to asymmetry is surrounded by 3 areas of integration.

Keywords: Autocatalysis, self-replication, self-reproduction, supramolecular chemistry, prebiotic chemistry

(Descriptions are provided by the Actions directly via e-COST.)

General Information*

Chair of the Action:

Prof Sijbren OTTO (NL)

Vice Chair of the Action:


Science officer of the Action:

Dr Lucia FORZI

Administrative officer of the Action:

Ms Svetlana VOINOVA


Action Fact Sheet

Download AFS as .RTF

Memorandum of Understanding

Download MoU as PDF

Progress Report

Download Progress Report as PDF


Download Poster as PDF


Last updated: 02 May 2011 top of page