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CA COST Action CA15106
C-H Activation in Organic Synthesis (CHAOS)

The main aim of this Action is to render C-H activation a truly versatile, practical and general tool for organic chemistry, applicable in both industry and academia.

In principal, organic chemists have the tools in hand to prepare any thermodynamically stable molecule by one way or the other. However, even though great achievements have been made in the past century, most of the bond forming reactions rely on preactivated substrates. Additionally, in complex synthesis, protecting group techniques are often required either to block alternative sites of reactivity, or to protect functional groups labile under reaction conditions required for a specific step of a sequence. The paradigm in organic synthesis has shifted from “getting the job done (the molecule synthesized)” towards getting the job done in the most efficient way possible. The method of metal catalysed C-H activation of organic small molecules has great potential in this regard. At the moment, the field includes many examples of transformations which can be carried out only on specific types of substrates and only few contributions deal with the application of C-H activation in the synthesis of complex molecules such as natural products. Additionally, applications of C-H activation in industrial processes are scarce. Hence, broad applicability, similar to the well establish cross-coupling reactions, has to be established. The time is ripe now to make a big collaborative effort in the area of C-H activation.

(Descriptions are provided by the Actions directly via e-COST.)

General Information*

Chair of the Action:

Prof Michael SCHN√úRCH (AT)

Vice Chair of the Action:


Science officer of the Action:

Dr Lucia FORZI

Administrative officer of the Action:



Action Fact Sheet

Download AFS as .RTF

Memorandum of Understanding

Download MoU as PDF


Action website:

* content provided by e-COST.
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Last updated: 13 November 2015 top of page