This page has beta status

BMBS COST Action BM1105
GnRH deficiency: Elucidation of the neuroendocrine control of human reproduction

Descriptions are provided by the Actions directly via e-COST.

The Action will investigate the neuroendocrine mechanisms that are integrated at the hypothalamic level and regulate the complex organ network controlling reproduction. Implicated genes/pathways have been identified through genetic investigations of rare patients with isolated GnRH deficiency, who display reproductive failure. Despite knowledge of 16 disease genes, multiple additional genes/mechanisms remain undiscovered, requiring higher-order collaborations for full elucidation. Through a collaborative network of physician-scientists and biologists, the Action will deliver: (i) a database with de-identified genetic and phenotypic data on at least 1,000 GnRH-deficient patients, their families, and unaffected controls; (ii) 1 or more disease gene(s) in each patient, and/or 10 or more novel disease genes; (iii) elucidation of newly identified genes’ roles in animal/cell-based systems; and (iv) guidelines for genetic counseling of GnRH-deficient patients based on the emerging disease architecture. Reasons for undertaking the Action in the COST framework are: (i) a critical yet disjointed mass of experts exists across Europe; (ii) participants are currently nationally funded; (iii) several participants’ countries do not participate in the e-RARE2 European funding scheme for rare diseases. European leadership in reproductive research/medicine will be augmented by the Action’s anticipated benefits; (i) collaboration among previously competing groups; (ii) shared use of cutting-edge genetic methodologies; and (iii) recruitment/training of young investigators.


General Information*

Chair of the Action:

Prof Nelly PITTELOUD (CH)

Vice Chair of the Action:

Dr Richard QUINTON (UK)

Science officer of the Action:

Dr Inga DADESHIDZE

Administrative officer of the Action:

Ms Gabriela CRISTEA

Downloads*

Action Fact Sheet

Download AFS as .RTF

Memorandum of Understanding

Download MoU as PDF

Progress Report

Download Progress Report as PDF

Websites*

Action website:

www.gnrhnetwork.eu

* content provided by e-COST.
Data is synchronised once per night.

Tools

Last updated: 03 December 2011 top of page

Follow COST on

  • Twitter
  • LinkedIn
  • Facebook
  • YouTube